effects of t-2 toxin on cytokine produc-tion by mice peritoneal macrophages and lymph node t-cells

background: t-2 toxin is a mycotoxin of type a trichothecenes produced by several fungal genera such as fusarium species. mycotoxins can affect both cell mediated and humoral immune compartments. objective: the purpose of this study was to investi-gate the effect of t-2 toxin on cytokine production by mouse peritoneal macrophages and lymph node t cells. methods: mouse peritoneal macrophages and lymph node t cells were isolated and treated with different concentrations of t-2 toxin and incubated at 370c and 5% co2 in air for 48 hours. cell free media were removed and used for cy-tokine assay by an elisa method. results: t-2 toxin significantly reduced il-1β re-lease in a concentration dependent manner (p